852 research outputs found
Effects of three-nucleon forces and two-body currents on Gamow-Teller strengths
We optimize chiral interactions at next-to-next-to leading order to
observables in two- and three-nucleon systems, and compute Gamow-Teller
transitions in carbon-14, oxygen-22 and oxygen-24 using consistent two-body
currents. We compute spectra of the daughter nuclei nitrogen-14, fluorine-22
and fluorine-24 via an isospin-breaking coupled-cluster technique, with several
predictions. The two-body currents reduce the Ikeda sum rule, corresponding to
a quenching factor q^2 ~ 0.84-0.92 of the axial-vector coupling. The half life
of carbon-14 depends on the energy of the first excited 1+ state, the
three-nucleon force, and the two-body current
Ab initio alpha-alpha scattering
Processes involving alpha particles and alpha-like nuclei comprise a major
part of stellar nucleosynthesis and hypothesized mechanisms for thermonuclear
supernovae. In an effort towards understanding alpha processes from first
principles, we describe in this letter the first ab initio calculation of
alpha-alpha scattering. We use lattice effective field theory to describe the
low-energy interactions of nucleons and apply a technique called the adiabatic
projection method to reduce the eight-body system to an effective two-cluster
system. We find good agreement between lattice results and experimental phase
shifts for S-wave and D-wave scattering. The computational scaling with
particle number suggests that alpha processes involving heavier nuclei are also
within reach in the near future.Comment: 6 pages, 6 figure
rac-(2R,3S)-2-Phenyl-3-(3-phenyl-1,2,3,4-tetraÂhydroÂquinoxalin-2-yl)quinoxaline
The title compound, C28H22N4, is the unexpected by-product of the reaction of 2-hydroxyÂacetophenone and 1,2-diaminoÂbenzene under iodine catalysis, during which a carbon–carbon σ-bond between two quinoxaline units was formed. Although a fully oxidized title compound should sterically be possible, only one quinoxaline ring is fully oxidized while the second ring remains in the reduced form. As expected, the tetraÂhydroÂquinoxaline unit is not planar; it adopts a sofa conformation, whereby the atom joining the two heterocyclic systems lies out of the plane of the other atoms. The quinoxaline ring system makes a dihedral angle of 53.61 (4)° with its phenyl ring substituent. The crystal packing is determined by pairs of N—H⋯N, N—H⋯π and weak C—H⋯N hydrogen bonds, forming a chain parallel to the a axis
Solar fusion cross sections II: the pp chain and CNO cycles
We summarize and critically evaluate the available data on nuclear fusion
cross sections important to energy generation in the Sun and other
hydrogen-burning stars and to solar neutrino production. Recommended values and
uncertainties are provided for key cross sections, and a recommended spectrum
is given for 8B solar neutrinos. We also discuss opportunities for further
increasing the precision of key rates, including new facilities, new
experimental techniques, and improvements in theory. This review, which
summarizes the conclusions of a workshop held at the Institute for Nuclear
Theory, Seattle, in January 2009, is intended as a 10-year update and
supplement to Reviews of Modern Physics 70 (1998) 1265.Comment: 54 pages, 20 figures, version to be published in Reviews of Modern
Physics; various typos corrected and several updates mad
Hidden spin-texture at topological domain walls drive exchange bias in a Weyl semimetal
Exchange bias is a phenomenon critical to solid-state technologies that
require spin valves or non-volatile magnetic memory. The phenomenon is usually
studied in the context of magnetic interfaces between antiferromagnets and
ferromagnets, where the exchange field of the former acts as a means to pin the
polarization of the latter. In the present study, we report an unusual instance
of this phenomenon in the topological Weyl semimetal Co3Sn2S2, where the
magnetic interfaces associated with domain walls suffice to bias the entire
ferromagnetic bulk. Remarkably, our data suggests the presence of a hidden
order parameter whose behavior can be independently tuned by applied magnetic
fields. For micron-size samples, the domain walls are absent, and the exchange
bias vanishes, suggesting the boundaries are a source of pinned uncompensated
moment arising from the hidden order. The novelty of this mechanism suggests
exciting opportunities lie ahead for the application of topological materials
in spintronic technologies.Comment: Main text: 11 pages, 4 figures. Supplementary information: 7 pages, 6
figures. Supplementary videos:
Solar fusion cross sections. II. The pp chain and CNO cycles
We summarize and critically evaluate the available data on nuclear fusion
cross sections important to energy generation in the Sun and other
hydrogen-burning stars and to solar neutrino production. Recommended values and
uncertainties are provided for key cross sections, and a recommended spectrum
is given for 8B solar neutrinos. We also discuss opportunities for further
increasing the precision of key rates, including new facilities, new
experimental techniques, and improvements in theory. This review, which
summarizes the conclusions of a workshop held at the Institute for Nuclear
Theory, Seattle, in January 2009, is intended as a 10-year update and
supplement to Reviews of Modern Physics 70 (1998) 1265.Comment: 54 pages, 20 figures, version to be published in Reviews of Modern
Physics; various typos corrected and several updates mad
Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor
The rational design of amyloid oligomer inhibitors is yet an unmet drug development need. Previous studies have identified the role of tryptophan in amyloid recognition, association and inhibition. Furthermore, tryptophan was ranked as the residue with highest amyloidogenic propensity. Other studies have demonstrated that quinones, specifically anthraquinones, can serve as aggregation inhibitors probably due to the dipole interaction of the quinonic ring with aromatic recognition sites within the amyloidogenic proteins. Here, using in vitro, in vivo and in silico tools we describe the synthesis and functional characterization of a rationally designed inhibitor of the Alzheimer's disease-associated β-amyloid. This compound, 1,4-naphthoquinon-2-yl-L-tryptophan (NQTrp), combines the recognition capacities of both quinone and tryptophan moieties and completely inhibited Aβ oligomerization and fibrillization, as well as the cytotoxic effect of Aβ oligomers towards cultured neuronal cell line. Furthermore, when fed to transgenic Alzheimer's disease Drosophila model it prolonged their life span and completely abolished their defective locomotion. Analysis of the brains of these flies showed a significant reduction in oligomeric species of Aβ while immuno-staining of the 3rd instar larval brains showed a significant reduction in Aβ accumulation. Computational studies, as well as NMR and CD spectroscopy provide mechanistic insight into the activity of the compound which is most likely mediated by clamping of the aromatic recognition interface in the central segment of Aβ. Our results demonstrate that interfering with the aromatic core of amyloidogenic peptides is a promising approach for inhibiting various pathogenic species associated with amyloidogenic diseases. The compound NQTrp can serve as a lead for developing a new class of disease modifying drugs for Alzheimer's disease
Lattice calculations for A=3,4,6,12 nuclei using chiral effective field theory
We present lattice calculations for the ground state energies of tritium,
helium-3, helium-4, lithium-6, and carbon-12 nuclei. Our results were
previously summarized in a letter publication. This paper provides full details
of the calculations. We include isospin-breaking, Coulomb effects, and
interactions up to next-to-next-to-leading order in chiral effective field
theory.Comment: 38 pages, 11 figures, final publication versio
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